Delta-8 is a selective cannabinergic compound that was originally developed by Daniel Siebert and attempts to mimic the effects of naturally occurring THC, while also adding in unique attributes and find out here now.
Delta-8 has also been reported to be highly effective in reducing intraocular pressure (IOP) when used as an eye drop; it can be found in dispensaries under the name Dronabinol. The product has garnered much attention for its use as a treatment for glaucoma and other forms of vision impairments. It’s currently used off-label, but recently GW Pharmaceuticals (developers of Sativex), began recruiting volunteers for clinical trials using Delta-8 to treat Glaucoma.
Delta-8 is most commonly smoked or vaporized rather than being orally administered. Due to Delta-8’s strong affinity for the CB1 receptor, it will attach itself to this receptor with greater frequency than THC which means that users will typically feel effects more quickly and they may also dissipate more rapidly as well. Users will likely know within minutes whether or not they’ve taken a hit of D-8 because of its rapid onset of action. The reason behind its short duration is due to the fact that delta 8 online only has a half-life of roughly 20 minutes in contrast to THC with an average half-life of 160 minutes (2 hours). As was mentioned earlier, 2C-I is also thought to metabolize into 8-OH-DPAT, which is a strong serotonin reuptake inhibitor. This means that users can expect to feel more intense ‘psychedelic’ effects when compared to traditional psychedelics, which typically work by agonizing 5-HT2 receptors.
When comparing the potency of Delta-8 to THC, it’s important to note that even though both drugs bind with high affinity for the CB1 receptor, they do so in many different ways. When smoking D-8, concentrations are much higher than when one smokes cannabis. Furthermore, 2C-I has been reported to have an effective dose range of roughly 15mg while THC requires around 100mg in order to reach similar effects.
Delta-8 is also known to antagonize the α3β4 nicotinic receptor (nAChR), which leads to temporary peripheral nerve stimulation. This effect is very common with other cannabinergic drugs, but it’s usually much more pronounced when consuming D-8. For this reason, many users report getting slight ‘cottonmouth’ and may also experience mild to moderate sweating. It should be noted that these effects are only temporary and will go away after roughly 20 minutes or so because 2C-I has a half-life of roughly 2 hours while THC’s half-life is around 9 hours.
